HCID 86622726, compound → HCID 86622725, compound

HRID 1673248Notes

Reaction equation

HRID 1673248 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([NH:10][NH2:11])=[O:9])[CH:5]=[CH:4][C:3]=1[C:12]1[N:17]=[C:16]2[O:18][C:19]([CH3:31])([CH3:30])[CH2:20][C@@H:21]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])[C:15]2=[CH:14][C:13]=1[C:32]1[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][CH:33]=1.Cl[C:40]1C=C(C(NO)=N)C=CC=1C1N=C2OC(C)(C)CC(NC(=O)C(C)(C)C)C2=CC=1C1C=CC(Cl)=CC=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]2[O:9][CH:40]=[N:11][N:10]=2)[CH:5]=[CH:4][C:3]=1[C:12]1[N:17]=[C:16]2[O:18][C:19]([CH3:31])([CH3:30])[CH2:20][C@@H:21]([NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:26])[CH3:27])[C:15]2=[CH:14][C:13]=1[C:32]1[CH:33]=[CH:34][C:35]([Cl:38])=[CH:36][CH:37]=1

Participants

3

Reactant 2

HCID 86622726HCID 86622726, compoundHCID 178426596HCID 178426596, compound

Product 1

HCID 86622725HCID 86622725, compound

Procedure

The product was prepared using the procedures analogous to those described for Example 318 substituting tert-butyl [(4R)-7-[2-chloro-4-(hydrazinocarbonyl)phenyl]-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]carbamate for N-[7-{2-chloro-4-[(hydroxyamino)(imino)methyl]phenyl}-6-(4-chlorophenyl)-2,2-dimethyl-3,4-dihydro-2H-pyrano[2,3-b]pyridin-4-yl]-2,2-dimethylpropanamide in Step B except without addition of boron trifluoride-diethyl etherate.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-355f9e57fdf84c60b952321b3eb3f1be
Source dataset
uspto-grants-2011_08
Patent number
US07999107B2

Reaction notes

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