Lithium Hydroxide → HCID 57965700, compound

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Reaction Steps

To a solution of {4-[2-(2-tert-butoxycarbonylamino-phenylcarbamoyl)-vinyl]-phenyl}-(3-hydroxy-pyrrolidin-1-yl)-acetic acid methyl ester (1.23 g, 2.5 mmol) in MeOH (30 mL) was added aqueous LiOH (1 N, 10 mL), This mixture was stirred for about 5 h at room temperature, and then evaporated to remove most of the MeOH. The aqueous layer was acidified with concentrated HCl to pH 5-6. The acidified aqueous layer was extracted with ethyl acetate (3×30 mL). The combined organic layer was washed with brine, dried with Na2SO4, filtered, and evaporated to obtain 0.85 g (81%) of a yellow solid product. MS: calc'd 482 (MH+), exp 482 (MH+).

Provenance & Evidence