HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-methyl-2-pyrrolidone → 4-(2-Phenylethyl)-1H-pyrazolo[3,4-b]pyridin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-Bromo-3-methoxycarbonyl-4-(2-phenylethyl)pyridine | HCID 23155330 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-(2-Phenylethyl)-1H-pyrazolo[3,4-b]pyridin-3-ol | HCID 178518963 | — |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 2-bromo-3-methoxycarbonyl-4-(2-phenylethyl)pyridine (1.42 g), hydrazine monohydrate (0.65 mL) and N-methylpyrrolidone (10 mL) was stirred at 100° C. for 2 hours. The reaction mixture was poured into water, and the precipitated crystals were collected by filtration, washed with water and dried under reduced pressure to give the title compound (0.74 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998975B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-cdb38088ba1b4713b7101ce0d5db454b |
| Source note | uspto-grants-2011_08 |