Hydrochloric Acid → HCID 57879406, compound

Participants

Reaction Steps

0.62 g of potassium carbonate and 0.43 ml of dimethyl sulfate were added to 15 mL of N,N-dimethylformamide solution containing 1.5 g of 2-(benzamido)-4-iodobenzoic acid at room temperature and stirred at the same temperature for 1 hour. Ethyl acetate and 1.0 mol/L hydrochloric acid were added to the reaction mixture. The organic layer was separated and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residual was purified with silica gel column chromatography [eluent; hexane:ethyl acetate=5:1] to obtain 1.3 g of methyl 2-(benzamido)-4-iodobenzoate as white solid.

Provenance & Evidence