反应详情

0.54 g of tetrakis(triphenylphosphine)palladium (0) was added to 35 mL of toluene solution containing 3.5 g of tert-butyl 2-(benzamido)-4-bromobenzoate and 5.0 g of tributylvinyl tin, and the resulting mixture was heated to reflux under nitrogen atmosphere for 2 hours. After the reaction mixture was cooled to room temperature, insoluble were removed by filtration, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [eluent; hexane; ethyl acetate=20:1] to obtain 1.4 g of tert-butyl 2-(benzamido)-4-vinylbenzoate as white solid.

1. temperaturethe resulting mixture was heated
2. temperatureto reflux under nitrogen atmosphere for 2 hours
3. custominsoluble were removed by filtration
4. customthe solvent was evaporated under reduced pressure
5. customThe obtained residue was purified with silica gel column chromatography [eluent; hexane; ethyl acetate=20:1]