Hydrochloric Acid → HCID 57879359, compound

Participants

Reaction Steps

To a solution of 5 mL of N,N-dimethylformamide containing 0.50 g of 2-methyl-5-phenoxyaniline hydrochloride, 0.91 mL of triethylamine and 0.27 mL of benzoyl chloride were added sequentially while ice-cooled sequentially and stirred at room temperature for 3 hours. Ethyl acetate and 1.0 mol/L hydrochloric acid were added to the reaction mixture. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with 1.0 mol/L hydrochloric acid, a saturated sodium hydrogen carbonate aqueous solution and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure. Hexane and diisopropyl ether were added to the obtained residue and a solid substance was separated by filtration to obtain 0.42 g of N-(2-methyl-5-phenoxyphenyl)benzamide as white solid.

Provenance & Evidence