反应详情

0.17 g of 5% palladium-carbon was added to a mixed solution of 8 mL of methanol and 8 mL of ethyl acetate containing 0.82 g of tert-butyl 2-nitro-4-phenoxybenzoate and stirred under hydrogen atmosphere at room temperature for 4 hours and 30 minutes. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [eluent; hexane; ethyl acetate=10:1] to obtain 0.63 g of tert-butyl 2-amino-4-phenoxybenzoate as colorless oil.

1. customInsoluble were removed by filtration
2. customthe solvent was evaporated under reduced pressure
3. customThe obtained residue was purified with silica gel column chromatography [eluent; hexane; ethyl acetate=10:1]