Dimethylformamide → HCID 57667896, compound

Participants

Reaction Steps

1.01 g of potassium carbonate and 0.39 mL of thiophenol were added to 10 mL of N,N-dimethylformamide solution containing 1.00 g of methyl 4-(bromomethyl)-2-nitrobenzoate at room temperature and stirred at the same temperature for 7 hours. Ethyl acetate was added to the reaction mixture and insoluble were removed by filtration and water was added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium hydrogen carbonate aqueous solution and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [eluent; hexane:ethyl acetate=4:1] to obtain 0.70 g of methyl 2-nitro-4-((phenylthio)methyl)benzoate as pale yellow oil.

Provenance & Evidence