Methanol → HCID 67343009, compound

Participants

Reaction Steps

0.33 g of 10% palladium-carbon was added to a mixed solution of 11 mL of methanol and 11 mL of ethyl acetate containing 1.1 g of tert-butyl 4-(3-chlorophenyl)-2-nitrobenzoate and stirred under hydrogen atmosphere at room temperature for 3 hours. After insoluble were removed by filtration, the solvent was evaporated under reduced pressure. 11 mL of acetic acid, 11 mL of methanol and 0.33 g of 10% palladium-carbon were added to the obtained residue sequentially and stirred under hydrogen atmosphere at room temperature for 2 hours. After insoluble were removed by filtration, the solvent was evaporated under reduced pressure to obtain 0.70 g of tert-butyl 2-amino-4-(3-chlorophenyl)benzoate as white solid.

Provenance & Evidence