Methanol → Tert-butyl 2-amino-4-(2,4-difluorophenyl)benzoate

Participants

Reaction Steps

0.27 g of 10% palladium-carbon was added to a mixed solution of 9.0 mL of methanol and 9.0 mL of ethyl acetate containing 0.90 g of tert-butyl 4-(2,4-difluorophenyl)-2-nitrobenzoate and stirred under hydrogen atmosphere at room temperature for 30 minuses. After insoluble were removed by filtration, the solvent was evaporated under reduced pressure to obtain 0.80 g of tert-butyl 2-amino-4-(2,4-difluorophenyl)benzoate as white solid.

Provenance & Evidence