Hydrochloric Acid → HCID 57879545, compound

Participants

Reaction Conditions

Reaction Steps

1.2 mL of 2.0 mol/L aqueous sodium hydroxide was added to a suspension of 5 mL of methanol and 2.5 mL of dioxane containing 0.50 g of methyl 2-(benzamido)-4-phenylbenzoate at room temperature and stirred at 50° C. for 30 minutes. After the reaction mixture was cooled to room temperature, 1.0 mol/L hydrochloric acid was added to adjust to pH 3 and water and ethyl acetate were added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. Hexane was added to the obtained, residue and a solid substance was separated by filtration to obtain 0.36 g of 2-(benzamido)-4-phenylbenzoic acid as white solid.

Provenance & Evidence