Hydrochloric Acid → HCID 57879353, compound

Participants

Reaction Conditions

Reaction Steps

0.83 mL of triethylamine, 34 mg of palladium acetate and 0.69 mL of styrene were added to 10 mL of N,N-dimethylacetamide solution containing 1.0 g of methyl 2-(benzamido)-1-bromobenzoate and 91 mg of tri(o-tolyl)phosphine, and stirred under nitrogen atmosphere at 120° C. for 1 hour and 30 minutes. After the reaction mixture was cooled to room temperature, 0.35 mL of styrene and 5 mg of palladium acetate were added and stirred at 120° C. for 2 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 1.0 mol/L hydrochloric acid were added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [eluent; hexane:ethyl acetate=8:1] to obtain 0.18 g of methyl 2-(benzamido)-4-((E)-2-phenylvinyl)benzoate as white solid.

Provenance & Evidence