Methanol → HCID 57879488, compound

Participants

Reaction Steps

0.37 mL of 2.0 mol/L aqueous sodium hydroxide was added dropwise to a mixed solution of 2 mL of methanol and 2 mL of tetrahydrofuran containing 0.18 g of methyl 2-(benzamido)-4-((E)-2-phenylvinyl)benzoate at room temperature, and stirred at the same temperature for 7 hours. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 4.0 with 1.0 mol/L hydrochloric acid. Solid substances were separated by filtration and purified with silica gel column chromatography [eluent; hexane:ethyl acetate=2:1] to obtain 65 mg of 2-(benzamido)-4-((E)-2-phenylvinyl)benzoic acid as white solid.

Provenance & Evidence