Methanol → 2-(Benzamido)-4-(phenylethynyl)benzoic acid

Participants

Reaction Steps

0.24 mL of 2.0 mol/L aqueous sodium hydroxide was added dropwise to a mixed solution of 1 mL of methanol and 2 mL of tetrahydrofuran containing 0.13 g of methyl 2-(benzamido)-4-(phenylethynyl)benzoate at room temperature and stirred at the same temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 4.0 while ice-cooled with 1.0 mol/L hydrochloric acid. A solid substance was separated by filtration to obtain 0.11 g of 2-(benzamido)-4-(phenylethynyl)benzoic acid as white solid.

Provenance & Evidence