Triphenylphosphine → Methyl 2-(benzamido)-4-(3-phenylpropoxy)benzoate

Participants

Reaction Steps

0.28 mL of 40% diisopropyl azodicarboxylate /toluene was added dropwise to 1 mL of tetrahydrofuran solution containing 0.10 g of methyl 2-(benzamido)-4-hydroxybenzoate, 0.060 mL of 3-phenyl-1-propanol and 0.15 g of triphenylphosphine at room temperature, and stirred at the same temperature for 2 hours and 30 minutes. The solvent was evaporated under reduced pressure, and the obtained residue was purified wish silica gel column chromatography [eluent; hexane:ethyl acetate=10:1] to obtain 45 mg of methyl 2-(benzamido)-4-(3-phenylpropoxy)benzoate as white solid.

Provenance & Evidence