Benzyl mercaptan → HCID 57879334, compound

Participants

Reaction Conditions

Reaction Steps

0.15 mL of triethylamine and 0.068 mL of benzyl mercaptan were added to 2 mL of toluene suspension containing 0.20 g of methyl 2-(benzamido)-4-iodobenzoate, 36 mg of 1,1′-bis(diphenylphosphino)ferrocene and 24 mg of tris(dibenzylideneacetone)dipalladium(0) and stirred under nitrogen atmosphere at 80° C. for 2 hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. The obtained, residue was purified with silica gel column chromatography [eluent; hexane; ethyl acetate=10:1] to obtain 0.16 g of methyl 2-(benzamido)-4-(benzylthio)benzoate as white solid.

Provenance & Evidence