3-Phenylpropylamine → HCID 67343242, compound

Participants

Reaction Conditions

Reaction Steps

53 mg of tris(dibenzylideneacetone)dipalladium(0) and 0.17 g sodium tert-butoxide were added to 5 mL of toluene solution containing 0.50 g of tert-butyl 2-(benzamido)-4-iodobenzoate, 0.25 mL of 3-phenylpropylamine and 36 mg of rac-2,2′-bis(diphenylphosphino)-1,1-binaphthyl at room temperature and stirred at 80° C. for 7 hours. After the reaction mixture was cooled to room temperature, insoluble were removed by filtration, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [eluent; hexane:ethyl acetate=6:1] to obtain 0.11 g of tert-butyl 2-(benzamido)-4-(3-phenylpropylamino)benzoate as brown oil.

Provenance & Evidence