Trifluoroacetic acid → HCID 57879388, compound

Participants

Reaction Steps

1.0 mL of trifluoroacetic acid solution containing 0.11 g of tert-butyl 2-(benzamido)-4-((3-phenylpropyl)amino)benzoate was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and ethyl acetate and water were added and pH was adjusted to pH 6.3 with a saturated sodium hydrogen carbonate aqueous solution. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure, Hexane and diisopropyl ether were added to the obtained residue and a solid substance was separated by filtration to obtain 71 mg of 2-(benzamido)-4-((3-phenylpropyl)amino)benzoic acid as white solid.

Provenance & Evidence