Methanol → HCID 57879469, compound

Participants

Reaction Steps

9 mg of 5% palladium-carbon was added to a mixed solution of 2.7 mL of methanol and 2.7 mL of ethyl acetate containing 30 mg of 2-benzamido-4-((E)-2-(3-chlorophenyl)vinyl)benzoic acid and stirred under hydrogen atmosphere at room temperature for 3 hours. Insoluble were removed by filtration and the solvent was evaporated under reduced pressure. The obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 60-100% acetonitrile/0.1% trifluoroacetic acid aqueous solution] to obtain 2.0 mg of 2-(benzamido)-4-(2-(3-chlorophenyl)ethyl)benzoic acid as white solid.

Provenance & Evidence