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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1673442Generated: October 26, 2026

Tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate → 2-(2,3-Dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid

https://huagongshe.com/reaction/1673442

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoateHCID 67342726—
SolventTrifluoroacetic acidHCID 6422—
Product2-(2,3-Dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acidHCID 57879479—

Reaction Steps

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(2,3-dimethylbenzamido)-4-(4-(tert-butoxycarbonyl)oxyphenyl)benzoate and stirred ah room temperature for 2 hours. The solvent was evaporated under reduced pressure and ethyl acetate was added to the obtained residue and a solid substance was separated by filtration to obtain 20 mg of 2-(2,3-dimethylbenzamido)-4-(4-hydroxyphenyl)benzoic acid as white solid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07999132B2
Source datasetuspto-grants-2011_08
ORD IDord-a30d5ffaa6034487adc5abfb425a26eb
Source noteuspto-grants-2011_08