Tert-butyl 4-(2,4-difluorophenyl)-2-(2,3-dimethylbenzamido)benzoate → 4-(2,4-Difluorophenyl)-2-(2,3-dimethylbenzamido)benzoic acid

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Reaction Steps

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-(2,4-difluorophenyl)-2-(2,3-dimethylbenzamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 17 mg of 4-(2,4-difluorophenyl)-2-(2,3-dimethylbenzamido)benzoic acid as white solid. 1H-NMR (DMSO-d6) δ: 2.31 (3H, s), 2.31 (3H, s), 7.21-7.30 (2H, m), 7.31-7.49 (4H, m), 7.63-7.70 (1H, m), 8.11 (1H, d, J=8.0 Hz), 8.89 (1H, s), 11.58 (1H, s).

Provenance & Evidence