HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-(Benzamido)-4-(4-phenoxyphenyl)benzoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 2-(benzamido)-4-(4-phenoxyphenyl)benzoate | HCID 67341966 | — |
| Product | 2-(Benzamido)-4-(4-phenoxyphenyl)benzoic acid | HCID 57879617 | — |
Reaction Steps
5.0 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(4-phenoxyphenyl)benzoate and stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and the obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; hexane:ethyl acetate=1:2] to obtain 8.0 mg of 2-(benzamido)-4-(4-phenoxyphenyl)benzoic acid as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07999132B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-4b2d5962791840d68a72072712525517 |
| Source note | uspto-grants-2011_08 |