Tert-butyl 2-(benzamido)-4-(4-hydroxyphenyl)benzoate → 2-(Benzamido)-4-(4-hydroxyphenyl)benzoic acid

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Reaction Steps

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 2-(benzamido)-4-(4-hydroxyphenyl)benzoate and stirred at room temperature for 1 hour. The solvent was evaporated under reduced pressure and the obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 55-90% acetonitrile /0.1% trifluoroacetic acid aqueous solution] to obtain 1.9 mg of 2-(benzamido)-4-(4-hydroxyphenyl)benzoic acid as while solid.

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