Trifluoroacetic acid → HCID 57879570, compound

Participants

Reaction Steps

5.0 mL of trifluoroacetic acid solution containing 75 mg of tert-butyl 2-(benzamido)-4-(indolin-1-yl)benzoate was stirred at room temperature for 1 hour and 30 minutes. The solvent was evaporated under reduced pressure, ethyl acetate and water were added and pH was adjusted to pH 6.5 with a saturated sodium hydrogen carbonate aqueous solution. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with water and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure. Methanol was added to the obtained residue and a solid substance was separated by filtration to obtain 51 mg of 2-(benzamido)-4-(indolin-1-yl)benzoic acid a yellow solid.

Provenance & Evidence