Tert-butyl 4-phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoate → 4-Phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoic acid

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Reaction Steps

10 mL of trifluoroacetic acid was added to the obtained tert-butyl 4-phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoate and stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure and water was added and pH was adjusted to pH 6.5 with a saturated sodium hydrogen carbonate aqueous solution. A solid substance was separated by filtration to obtain 56 mg of 4-phenyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoic acid as white solid.

Provenance & Evidence