2-Methoxybenzoic acid → HCID 67342584, compound

Participants

Reaction Steps

1.0 mL of methylene chloride, 2.7 pit of N,N-dimethylformamide and 0.061 mL of oxalyl chloride were added to 0.11 g of 2-methoxybenzoic acid at room temperature sequentially and stirred at the same temperature for 1 hour. The reaction mixture was added to a mixed solution of 4.0 mL of methylene chloride and 0.45 mL triethylamine containing 57 mg of tert-butyl 2-amino-4-phenoxybenzoate and stirred at room temperature for 1 hour. A saturated sodium hydrogen carbonate aqueous solution was added to the reaction mixture, and the organic layer was separated, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex Company, eluent; hexane:ethyl acetate=4:1] to obtain tert-butyl 2-(2-methoxybenzamido)-4-phenoxybenzoate.

Provenance & Evidence