Hydrochloric Acid → HCID 46245545, compound

Participants

Reaction Conditions

Reaction Steps

1.0 mL of 2.0 mol/L aqueous sodium hydroxide and 3.0 mL of ethanol were added to the obtained methyl 2-(4-methoxybenzamido)-4-phenylbenzoate and stirred at 40° C. for 2 hours. After the reaction mixture was cooled to room temperature, 8.0 mL of 0.38 mol/L hydrochloric acid and 10 mL of ethyl acetate were added. The organic layer was separated and dried over anhydrous magnesium sulfate, and the solvent was evaporated under reduced pressure. The obtained residue was purified with reversed-phase silica gel column chromatography [eluent; 55-100% acetonitrile /0.1% trifluoroacetic acid aqueous solution] to obtain 6.1 mg of 2-(4-methoxybenzamido)-4-phenylbenzoic acid as white solid.

Provenance & Evidence