Hydrochloric Acid → Tert-butyl 2-(biphenyl-3-carboxamido)-4-phenoxybenzoate

Participants

Reaction Steps

4.0 mL of methylene chloride, 0.015 mL of N-dimethylformamide and 0.050 mL of oxalyl chloride were added to 99 mg of 3-biphenylcarboxylic acid at room temperature sequentially and stirred at the same temperature for 20 minutes. 0.16 mL of triethylamine and 0.13 g of tert-butyl 2-amino-4-phenoxybenzoate were added to the reaction mixture at room temperature sequentially and stirred at the same temperature for 10 minutes. Ethyl acetate and 1.0 mol/L hydrochloric acid were added to the reaction mixture. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with a saturated sodium chloride aqueous solution, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [PSQ100B (spherical) manufactured by Fuji Silysia Chemical Ltd., eluent; chloroform] to obtain 14 mg of tert-butyl 2-(biphenyl-3-carboxamido)-4-phenoxybenzoate as white solid.

Provenance & Evidence