Trifluoroacetic acid → HCID 57879360, compound

Participants

Reaction Steps

1.7 mL of trifluoroacetic acid was added to 0.17 g of tert-butyl 4-phenethyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoate and stirred at room temperature for 3 hours. The solvent was evaporated under reduced pressure, and hexane and diisopropyl ether were added to the obtained residue and a solid substance was separated by filtration. Ethyl acetate and water were added to the obtained solid substance and pH was adjusted to pH 6.8 with a saturated sodium hydrogen carbonate aqueous solution. A solid substance was separated by filtration to obtain 65 mg of 4-phenethyl-2-(6-(piperidin-1-yl)pyridine-3-carboxamido)benzoic acid as white solid.

Provenance & Evidence