Hydrochloric Acid → HCID 57879382, compound

Participants

Reaction Conditions

Reaction Steps

0.094 mL of 2.0 mol/L aqueous sodium hydroxide was added to a mixed solution of 1.5 mL of dioxane and 1.5 mL of methanol containing 50 mg of methyl 2-(benzamido)-4-(1-methyl-1H-indol-5-yloxy)benzoate at room temperature, stirred at 50° C. for 1 hour, and 0.031 mL of 2.0 mol/L aqueous sodium hydroxide was added at the same temperature and then stirred at 50° C. for 30 minutes. After the reaction mixture was cooled to room temperature, water was added and pH was adjusted to pH 3.5 with 1.0 mol/L hydrochloric acid and ethyl acetate was added. The organic layer was separated and dried over anhydrous magnesium sulfate after washed with water and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure. Hexane was added to the obtained residue and a solid substance was separated by filtration to obtain 37 mg of 2-(benzamido)-4-(1-methyl-1H-indol-5-yloxy)benzoic acid as white solid.

Provenance & Evidence