Hydrochloric Acid → HCID 57879364, compound

Participants

Reaction Conditions

Reaction Steps

0.22 g of aluminum chloride was added to 1.0 ml of toluene solution containing 0.10 g of 2-(benzamido)-4-(3-methoxyphenoxy)benzoic acid at room temperature and stirred at 80° C. for 8 hours. After the reaction mixture was cooled to room temperature, ethyl acetate and 1.0 mol/b hydrochloric acid were added. The organic layer was separated, and dried over anhydrous magnesium sulfate after washed with 1.0 mol/L hydrochloric acid and a saturated sodium chloride aqueous solution sequentially, and the solvent was evaporated under reduced pressure. The obtained residue was purified with silica gel column chromatography [Flash Tube 2008 manufactured by Trikonex Company, eluent; hexane:ethyl acetate; acetic acid=15:10:1]to obtain 54 mg of 2-(benzamido)-4-(3-hydroxyphenoxy)benzoic acid as white solid.

Provenance & Evidence