Dichloromethane → HCID 57879620, compound

Participants

Reaction Steps

1.0 mL of trifluoroacetic acid was added to 4.0 mL of methylene chloride solution containing the obtained tert-butyl 5-(3-(benzamido)-4-(tert-butoxycarbonyl)phenoxy)-1H-indole-1-carboxylate while ice-cooled and stirred at the same temperature for 2 hours and 30 minutes. After the reaction mixture was warmed to room temperature, ethyl acetate and a saturated sodium hydrogen carbonate aqueous solution were added. The aqueous layer was separated and washed with ethyl acetate after adjusted to pH 6.5 with 6.0 mol/L hydrochloric acid and allowed to stand still for 17 hours. A solid substance was separated by filtration to obtain 10 mg of 2-(benzamido)-4-(1H-indol-5-yloxy)benzoic acid as white solid.

Provenance & Evidence