HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(3-(Bromomethyl)phenyl)ethan-1-one → Ethyl 2-(3-acetylbenzyl)-3-oxobutanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(3-(Bromomethyl)phenyl)ethan-1-one | HCID 15479807 | — |
| Reactant | Ethyl acetoacetatesodium salt | HCID 87089461 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Ethyl 2-(3-acetylbenzyl)-3-oxobutanoate | HCID 57460081 | 49.1% |
Reaction Steps
A solution of 3-acetylbenzyl bromide (4 g) and ethyl acetoacetate sodium salt (3.42 g) in tetrahydrofuran (50 mL) was stirred for 12 hr. The insoluble material was filtered off and the filtrate was concentrated. The residue was purified by silica gel column chromatography to give the title compound (2.42 g, 49%) as a colorless viscous oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998968B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-80deb4ce116f4a2ca83522051f2b0db0 |
| Source note | uspto-grants-2011_08 |