Diisopropyl Ether → 3-(4-Isopropoxyphenyl)-2-methyl-5-{[2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3h)-one potassium salt

Participants

Reaction Conditions

Reaction Steps

To a suspension of 3-(4-isopropoxyphenyl)-2-methyl-5-{[2′-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl}-6-propylpyrimidin-4(3H)-one (200 g), ethanol (200 mL), and diisopropyl ether (400 mL) was added potassium 2-ethyl hexanoate and the mixture was stirred at 60° C. for 1 hr. To the mixture was added diisopropyl ether (1000 mL) dropwise. The mixture was stirred at reflux temperature for 24 hr, followed by being cooled to room temperature. The obtained precipitate was collected, washed with diisopropyl ether, and dried under reduced pressure at 60° C. for 1 hr to give the title compound (120 g, 56%) as colorless crystals.

Provenance & Evidence