HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxoheptanoate → HCID 136026916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 2-[(2'-cyanobiphenyl-4-yl)methyl]-3-oxoheptanoate | HCID 10807723 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 3-Methoxypropanimidamide--hydrogen chloride (1/1) | HCID 19847582 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 136026916 | HCID 136026916 | 44% |
Reaction Steps
A solution of 3-methoxypropanimidamide hydrochloride (4.0 g), 28% sodium methoxide (8.7 mL) and methyl 2-[(2′-cyanobiphenyl-4-yl)methyl]-3-oxoheptanoate (5.0 g) in methanol (50 mL) was stirred overnight. The solvent was evaporated under reduced pressure, and water and 1 M hydrochloric acid were added. The precipitated solid was collected by filtration, and washed with water and diethyl ether to give the title compound (2.5 g, 44%) as a pale-yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07998968B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-973f336bf1cc4f8fb714995913869af2 |
| Source note | uspto-grants-2011_08 |