Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Toluene | HCID 1140 | — |
| Reactant | Potassium Phosphate, Tribasic | HCID 62657 | — |
| Reactant | 2,3-Difluorophenol | HCID 80879 | — |
| Reactant | HCID 178455773 | HCID 178455773 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 178455765 | HCID 178455765 | — |
Reaction Steps
In DMF, trans-4-(trans-4-vinylcyclohexyl)cyclohexylmethyl methanesulfonate was dissolved, and 2,3-difluorophenol and tripotassium phosphate were added thereto, and then stirred for 2 hours at 80 to 100° C. Water and toluene were added thereto, and the organic layer was fractioned. The resultant product was washed with water and saturated saline, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by column chromatography, to thereby obtain 2,3-difluoro-1-(trans-4-(trans-4-vinylcyclohexyl)cyclohexyl)methoxybenzene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08003006B2 |
|---|
| Source dataset | uspto-grants-2011_08 |
|---|
| ORD ID | ord-55d822642f25466f83a4b3ec3cde49a0 |
|---|
| Source note | uspto-grants-2011_08 |
|---|
