Water → HCID 178455767, compound

Participants

Reaction Conditions

Reaction Steps

6.5 g of 2,3-difluoro-4-(trans-4-(trans-4-vinylcyclohexyl)cyclohexyl)methoxyphenol was dissolved in 35 mL of DME, and 4.9 g of (trans-4-ethylcyclohexyl)methyl bromide and 6.4 g of tripotassium phosphate were added thereto, and then stirred for 2 hours at 80 to 100° C. Water and toluene were added thereto, and the organic layer was fractioned. The resultant product was washed with saturated saline, and then dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure. The residue was purified by recrystallization and column chromatography, to thereby obtain 3.8 g of 2,3-difluoro-1-(trans-4-ethylcyclohexyl)methoxy-4-(trans-4-(trans-4-vinylcyclohexyl)cyclohexyl)methoxybenzene (1a) in the form of colorless crystals.

Provenance & Evidence