Water → HCID 178455776, compound

Participants

Reaction Conditions

Reaction Steps

30 g of 2,3-difluorophenol was dissolved in 300 ml of DMF, and 56.8 g of (trans-4-ethylcyclohexyl)methyl bromide and 73.4 g of tripotassium phosphate were added thereto, and then stirred for 1 hours at 100 to 110° C. Water and toluene were added thereto, and the organic layer was fractioned while the aqueous layer was extracted with toluene. The organic layers were combined, washed with saturated saline, and then subjected to column chromatography. Then, the solvent was evaporated under reduced pressure. The residue was purified by recrystallization, to thereby obtain 37 g of 2,3-difluoro-1-(trans-4-ethylcyclohexyl)methoxybenzene.

Provenance & Evidence