Hydrochloric Acid → HCID 178445647, compound

Participants

Reaction Steps

3 g of 1-((trans-4-(3-butenyl)cyclohexyl)methoxy)-2,3-difluorobenzene was dissolved in 30 mL of THF, and 11.7 mL of sec-butyllithium (1.01 M cyclohexane, a hexane solution) was added dropwise thereto at an internal temperature of −40 to −60° C. Then, the solution was stirred for 30 min. To this solution, 1.3 g of trimethyl borate was added, and the solution was heated to room temperature. Then, 1.8 mL of 30% hydrogen peroxide solution was added thereto, and the solution was stirred at 40° C. for 1 hours. To the solution, 5% hydrochloric acid was added, and the solution was stirred for 1 hour. Toluene was added thereto, and the organic layer was fractioned, washed with saturated saline, and then dried over anhydrous magnesium sulfate, to thereby obtain 4-((trans-4-(3-butenyl)cyclohexyl)methoxy)-2,3-difluorophenol.

Provenance & Evidence