3-Aminophenol → 2-ethyl-N,N'-bis(3-hydroxyphenyl)pyrimidine-4,6-diamine

HRID 1674506Notes

Reaction equation

HRID 1674506 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.Cl[C:10]1[CH:15]=[C:14](Cl)[N:13]=[C:12]([CH2:17][CH3:18])[N:11]=1>C(OCCO)C>[CH2:17]([C:12]1[N:13]=[C:14]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[CH:3]=2)[CH:15]=[C:10]([NH:1][C:2]2[CH:7]=[CH:6][CH:5]=[C:4]([OH:8])[CH:3]=2)[N:11]=1)[CH3:18]

Participants

4

Reactant 2

HCID 115683-AminophenolHCID 5184654,6-Dichloro-2-ethylpyrimidine

Product 1

HCID 98801932-ethyl-N,N'-bis(3-hydroxyphenyl)pyrimidine-4,6-diamine

Reagents, catalysts & solvents 1

HCID 8076Glycol monoethyl etherSolvent

Procedure

After dissolving 3-aminophenol (1.09 g, 10.0 mmol) in 2-ethoxyethanol (5.0 mL), 4,6-dichloro-2-ethylpyrimidine (0.89 g, 5.0 mmol) was added and stirring carried out for 5 hours at 130° C.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-90ad7d9676e848649766fa7eaa8671ac
Source dataset
uspto-grants-2011_08
Patent number
US08003645B2

Reaction notes

Loading…