4,6-Dichloro-2-(methylthio)pyrimidine → HCID 66991899, compound

HRID 1674509Notes

Reaction equation

HRID 1674509 reaction equation
Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([S:9][CH3:10])[N:3]=1.[CH2:11]([NH:13][C:14]1[CH:15]=[C:16]([OH:20])[CH:17]=[CH:18][CH:19]=1)[CH3:12]>>[CH3:10][S:9][C:4]1[N:5]=[C:6]([N:13]([CH2:11][CH3:12])[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=2)[CH:7]=[C:2]([N:13]([CH2:11][CH3:12])[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([OH:20])[CH:15]=2)[N:3]=1

Participants

3

Reactant 2

HCID 805314,6-Dichloro-2-(methylthio)pyrimidineHCID 5789913-Ethylaminophenol

Product 1

HCID 66991899HCID 66991899, compoundYield 43%

Procedure

This compound was obtained (yield 43%) based on the method described in Production Example 2B using 4,6-dichloro-2-methylthio-pyrimidine instead of the 4,6-dichloro-2-ethylpyrimidine, and using 3-ethylaminophenol instead of the 3-aminophenol.

Workup

  1. customThis compound was obtained (yield 43%)

Sources & evidence

ORD record
ord-72aaebd6dd38411091691b2fdee932fe
Source dataset
uspto-grants-2011_08
Patent number
US08003645B2

Reaction notes

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