4,6-Dichloro-2-methylpyrimidine → HCID 66991427, compound

HRID 1674512Notes

Reaction equation

HRID 1674512 reaction equation
Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([CH3:9])[N:3]=1.[NH2:10][C:11]1[C:12]([F:19])=[CH:13][C:14]([F:18])=[C:15]([OH:17])[CH:16]=1>>[CH3:9][C:4]1[N:5]=[C:6]([NH:10][C:11]2[C:12]([F:19])=[CH:13][C:14]([F:18])=[C:15]([OH:17])[CH:16]=2)[CH:7]=[C:2]([NH:10][C:11]2[C:12]([F:19])=[CH:13][C:14]([F:18])=[C:15]([OH:17])[CH:16]=2)[N:3]=1

Participants

3

Reactant 2

HCID 2349974,6-Dichloro-2-methylpyrimidineHCID 27829995-Amino-2,4-difluorophenol

Product 1

HCID 66991427HCID 66991427, compoundYield 57%

Procedure

This compound was obtained (yield 57%) based on the method described in Production Example 2B using 4,6-dichloro-2-methylpyrimidine instead of the 4,6-dichloro-2-ethylpyrimidine, and using 5-amino-2,4-difluorophenol instead of the 3-aminophenol.

Workup

  1. customThis compound was obtained (yield 57%)

Sources & evidence

ORD record
ord-0486cbc9b83b446dbcd41be5bf87d6d0
Source dataset
uspto-grants-2011_08
Patent number
US08003645B2

Reaction notes

Loading…