4,6-Dichloro-2-methylpyrimidine → HCID 85836153, compound

HRID 1674513Notes

Reaction equation

HRID 1674513 reaction equation
Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([CH3:9])[N:3]=1.[NH2:10][C:11]1[CH:12]=[C:13]([OH:21])[CH:14]=[C:15]([C:17]([F:20])([F:19])[F:18])[CH:16]=1>>[CH3:9][C:4]1[N:5]=[C:6]([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:14]=[C:13]([OH:21])[CH:12]=2)[CH:7]=[C:2]([NH:10][C:11]2[CH:16]=[C:15]([C:17]([F:18])([F:19])[F:20])[CH:14]=[C:13]([OH:21])[CH:12]=2)[N:3]=1

Participants

3

Reactant 2

HCID 2349974,6-Dichloro-2-methylpyrimidineHCID 144012293-aMino-5-(trifluoroMethyl)phenol

Product 1

HCID 85836153HCID 85836153, compoundYield 43%

Procedure

This compound was obtained (yield 43%) based on the method described in Production Example 2B using 4,6-dichloro-2-methylpyrimidine instead of the 4,6-dichloro-2-ethylpyrimidine, and using 3-amino-5-trifluoromethyl-phenol instead of the 3-aminophenol.

Workup

  1. customThis compound was obtained (yield 43%)

Sources & evidence

ORD record
ord-bb7d696d2c4a4793b040f2030864a376
Source dataset
uspto-grants-2011_08
Patent number
US08003645B2

Reaction notes

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