4,6-Dichloro-2-methylpyrimidine → HCID 66990956, compound

HRID 1674515Notes

Reaction equation

HRID 1674515 reaction equation
Cl[C:2]1[CH:7]=[C:6](Cl)[N:5]=[C:4]([CH3:9])[N:3]=1.[CH3:10][NH:11][C:12]1[CH:13]=[C:14]([OH:18])[CH:15]=[CH:16][CH:17]=1>>[CH3:9][C:4]1[N:5]=[C:6]([N:11]([CH3:10])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=2)[CH:7]=[C:2]([N:11]([CH3:10])[C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([OH:18])[CH:13]=2)[N:3]=1

Participants

3

Reactant 2

HCID 2349974,6-Dichloro-2-methylpyrimidineHCID 108205133-(Methylamino)phenol

Product 1

HCID 66990956HCID 66990956, compoundYield 45%

Procedure

This compound was obtained (yield 45%) based on the method described in Production Example 2B using 4,6-dichloro-2-methylpyrimidine instead of the 4,6-dichloro-2-ethylpyrimidine, and using 3-methylaminophenol instead of the 3-aminophenol.

Workup

  1. customThis compound was obtained (yield 45%)

Sources & evidence

ORD record
ord-5e62651ec43740a095cf09a9f6774719
Source dataset
uspto-grants-2011_08
Patent number
US08003645B2

Reaction notes

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