反应详情

A solution of N-(2-chloro-5-hydroxymethyl-phenyl)-3,4-dimethoxy-benzenesulfonamide (2.53 g, 7 mmol) in DCM/THF (1:1, 16 mL) was treated with MnO2 (12.3 g, 20 eq). The mixture was stirred at RT for 6 h, filtered over Celite and concentrated. The residue purified by chromatography on SiO2 (hex/EA 1:1, EA). The product was recovered as a pinkish oil (1.95 g, 77%).

1. filtrationfiltered over Celite
2. concentrationconcentrated
3. customThe residue purified by chromatography on SiO2 (hex/EA 1:1, EA)
4. customThe product was recovered as a pinkish oil (1.95 g, 77%)