反应详情

A solution of N-[2-chloro-5-(1-hydroxy-ethyl)-phenyl]-3,4-dimethoxy-benzenesulfonamide (1.85 g, 5 mmol) in DCM/THF (1:1, 10 mL) was treated with MnO2 (10.8 g, 25 eq). The mixture was stirred at RT for 7 h, filtered over Celite and concentrated. The residue was purified by chromatography on SiO2 (hex/EA 1:1). The product was recovered as a colourless foam (1.58 g, 86%).

1. filtrationfiltered over Celite
2. concentrationconcentrated
3. customThe residue was purified by chromatography on SiO2 (hex/EA 1:1)
4. customThe product was recovered as a colourless foam (1.58 g, 86%)