Triethylamine → HCID 42633023, compound

Participants

Reaction Steps

1.4 mmol of 4-nitrophenylformiate are added to a solution of 1 mmol of (3R,4R,5R)-3-aminomethyl-4-[4-((R)-2-ethoxy-propoxymethyl)-phenyl]-5-[4-(3-methoxy-propyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-piperidine-1-carboxylic acid benzyl ester (example 6a) in 10 ml of CH2Cl2 under argon followed by the addition of 1 mmol of Et3N. After 60 min, the reaction mixture is evaporated. The residue is purified by flash chromatography (SiO2 60F) to afford the title compound, which is identified based on the Rf value.

Provenance & Evidence