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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1674696Generated: October 31, 2026

3-(Trifluoromethyl)phenyl isocyanate → 1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)urea

https://huagongshe.com/reaction/1674696

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(Trifluoromethyl)phenyl isocyanateHCID 9483—
Reactant4-(Tetramethyl-1,3,2-dioxaborolan-2-yl)anilineHCID 2734620—
Product1-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-3-(3-(trifluoromethyl)phenyl)ureaHCID 16125103—

Reaction Steps

Intermediate 19 was prepared in analogy to GP 3 by reaction of 4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine with 1-isocyanato-3-trifluoromethylbenzene.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08003655B2
Source datasetuspto-grants-2011_08
ORD IDord-8767990f8bf444398e98563d7b5d9997
Source noteuspto-grants-2011_08