HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyridine → 2,3-Dichloro-N-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyridine | HCID 1049 | — |
| Reactant | 2,3-Dichlorobenzene-1-sulfonyl chloride | HCID 2734222 | — |
| Reactant | 2-Fluoro-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | HCID 17906172 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2,3-Dichloro-N-(2-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzenesulfonamide | HCID 58696159 | — |
Reaction Steps
Intermediate 25 was prepared in analogy to GP 4 from 1.78 g 2-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenylamine (7.5 mmol) and 2.03 g 2,3-dichloro-benzenesulfonyl chloride (8.25 mmol, 1.1 eq.) in 20 mL DCM and in the presence of 0.66 mL pyridine (8.25 mmol, 1.1. eq.) yielding after trituration 2.42 g of the target compound (72% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08003655B2 |
| Source dataset | uspto-grants-2011_08 |
| ORD ID | ord-f9b4c3a0e70542e5b0254c45057dfeb2 |
| Source note | uspto-grants-2011_08 |