Methanol → HCID 57614150, compound

Participants

Reaction Conditions

Reaction Steps

5-Chloro-6-(4-fluorophenyl)[1,3]thiazolo[5,4-d]pyrimidin-7(6H)-one (0.2 mmol) and 2.4-difluorophenol (0.4 mmol) are added to a vial, and the sealed mixture is heated with stirring at 140° C. for 48 h. Silica gel column chromatography (MeOH:CH2Cl2=0.5:99.5) gives the title compound as a slightly yellow solid. 1H NMR (400 MHz, CDCl3) 8.70 (1H, s), 7.36 (2H, m), 7.26 (2H, m), 7.14 (1H, m), 6.94 (2H, m). MS (M+1): 376.03; RT=1.33 min.

Provenance & Evidence